Brown had been a longtime blogger for People.com, documenting her brave cancer struggle for the past couple years.
“MTV is tremendously sad to hear the news that Diem Brown has lost her long battle with cancer,” MTV added via a statement. “We send our deepest condolences to her family and friends. Diem was a true fighter and brought passion to everything she touched. We will miss her.”
Just a couple days ago on Tuesday, the reality star had asked for prayers and advice, tweeting, "my doctors are seemingly giving up but I won't & can't rollover. Whatever option I have to LIVE I'm grabbing!"
Last month, Brown revealed to
People magazine that her latest bout with cancer had spread from her colon to her liver and lymph nodes.
"I was blown away. It really crushed a little bit of my spirit," she said.
After dealing with intense pain and side effects from the chemotherapy, Brown said she was at her lowest point in late October.
"It was such a dark, dark, dark, dark place. I would go in the bathtub and just lay down for hours, with the water running," she added. "I kept getting worse, and I felt like it would never end."
But through it all, Brown never lost her spirit and always stayed positive, even thinking about her post-cancer life.
"I'm going to have a family and get married and the whole American, 2½ kids, white-picket-fence dream," she said. "It's something that's really important to me, because it means a long-term future."
Brown -- who made her MTV debut on "Real World/Road Rules Challenge: Fresh Meat" in 2006, then went on to create
MedGift, a website to support others like her fighting serious health issues -- had been dealing with cancer for almost a decade. First with ovarian cancer in 2006 and then again in 2012. She was noticeably surprised when it returned the second time.
"My doctors said there was no way it would come back," she told
US Weekly in 2012. "I got a call from the same doctor I had six years ago and he said those same words, they're just as devastating: 'Sorry to tell you, but you have cancer.'"
Then in 2013, she beat cancer once again.
"The call came – the call that made me feel like I had a map leading me out of my maze, doors started lifting up and I was finally let free," she wrote for
People.com in February of that year. "That first breath you let out when you get good news feels almost stolen. Your entire body gets weak as if you were holding up this 100-lb. weight over your head and you've finally been told you could drop it. You feel free! Absolutely freaking free!"
But once again, the MTV star was diagnosed with cancer this past August, this time in her colon.
"The Duel" and "The Gauntlet" competitor found out about the news while filming a reality show.
"Doctors found one tumor blocking her colon completely so they had to do emergency surgery that evening to remove the blockage," Brown's sister told People. She had a second surgery three days later.
Location
Through it all, it was her MTV family that stood by Brown through her battles.
Earlier last month, Brown posted a photo of a letter she received from a fellow challenge cast member Cara Maria.
"After back tube surgery I opened most thoughtful @CaraMariaMTV letter!," she wrote.
Former MTV host TJ Lavin reached out to see how she was doing, as well.
"Been a tough week but you of all people understand the roller coaster of recovery?? thx for ur support!" she replied.
